A GLORIOUS CHANGE, That'any sick man survived the treatment of fifty yeiiFrs ago must be considered a proof that human beings are very hard to kill. The lancet, calomel, cantharid.es and drastic purgatives were thai the.order of the day. The physician played into the hands of the apothecary, and the unfortunate patient was drenched, morning, noon and night, with prostrating medicines. We live in a more rational and conscientious era; the importance of supporting Nature in its conflict with disease is now understood. Complaints, in themselves weakening, arc no longer aggravated by artificial depletion ; they are met with T( )N 1CS that rally the vital powers and enable them to defeat the i r.rmy. Chief among these allies of Nature in its battles with sickness is PLANTATION BITTERS. This wonderful vegetable restorative is the sheet-anchor of t:the feeble-and debilitated. As a cordial for the aged and decrepit jit has no equal among stomachics. : As a remedy tor the nervous 'weakness to which the tender sex are .especially subject, it is superseding every other stimulant and nervine. in all climates, tropical, temperate or frigid, it acts as a specific in every species of disorder which undermines,the iTodily strength and breaks down the animal spirits. Wherever it is introduced it becomes a ^ndard articlea medicinal staple. Druggists, although their profit upon it is small, find it absolutely necessary to keep a preparation for wnich every body inquires, au.i.for which-nobody will accept a substitute. It is to-day the most popular medicine in the civilized world.-Extensively as it is advertised, its best advertisement is the beneficial result which uniformly follows its use. Every bottle sold insures the sale of at least half a dozen more. Unlike other stimulants it; braces and fortifies the system without exciting undue cerebral action. The cheering effect which it produces upon the mind is not momentary, but permanent; there is no subsequent depression. It does not, as is the case with all other stimuli, beget a craving for excitants. On the ether hand it soothes and calms the nerves, combining, strange as the anomaly may*seem, the qualities of a sedative and gentle anodyne, with those of a tonic and invigorant. The perfect purity of all ingredients, their admirable adaptation to the purposes the are intended to subserve, the judicious proportions in whirl j U»e are combined, and the scientific skill with which: they are ; hlended, render, this famous article at once the most-potent, and 11»< - mo i harmless ©f all known tonics and alteratives.;" ^ SOLD BY ALL DRUGGISTS.