'Wellcome' Standards * The paramount importance of the highest obtainable degree of purity of medicinal chemicals has always been insisted upon by B. W. & Co. The official standards in many cases leaving much room for improvement, and being of necessity liable to get out of date, it has been thought desirable to indicate the standards adopted for ' Wellcome' Brand Chemicals and Galenicals. It should be noted, however, that these standards are under constant revision as the results of investigation render it advisable. Product Aconitine (Pure Alkaloid) Aloin ......... Atropine (Pure Alkaloid), B.P. Atropine Sulphate Bismuth Carbonate, B.P. Bismuth Citrate ... Bismuth Oxychloride Bismuth Salicylate Bismuth Subgallate Bismuth Subnitrate Calcium Glycerophosphate Calcium Hypophosphite, B.P. , Chloroform Cocaine (Pure Alkaloid), B.P. , Standard M.p. 2O2°-2O4°; [«]D + 17° (in chloroform) Well-defined bright yellow crystals ; clear solution (10 %) in water or alcohol M.p. u6° ; optical rotation for a 10 per cent, solution in a 2 dcm. tube not exceeding -oi° M.p. 196°after drying; optical rotation for a 10 per cent, solution in a 2 dcm. tube not exceeding -o-i° White, uniform lightness (constant volume per unit weight). Nitrate present not exceeding 0-15 per cent, of N2O5 Readily soluble in ammonia; nitrate present not exceeding 0-05 per cent, of NoO.. Affords 5 6-5 8 per cent, of Bi o O:J Uniform lightness (constant volume per unit weight) ; affords 88-5-89-5 per cent, of Bi2O3 Affords 63-65 per cent, of Bi.2O3 ; free salicylic acid not exceeding 01 per cent. Uniform lightness ; affords about 53 per cent, of Bi2O:3 Uniform lightness (constant volume per unit weight) Soluble in 30 parts of cold water, forming a perfectly bright solution Not less than 99-5 per cent, of Ca P2H4O4. Aqueous solution (10 %) should be perfectly bright B.p. 6o°-62°; meets all the official requirements and contains an unvarying amount of ethyl chloride M.p. 980; answers the most stringent permanganate test